The Moderna nor Pfizer vaccines, made from an entirely different technology called Whether the viral vector had some part to play.

When both vaccines showed the ultra-rare side effect of VITT, scientists wondered “Our data confirms PF4 can bind to adenoviruses,Īn important step in unravelling the mechanism underlying VITT.” Of Medicine and first author of the study. In the use of adenoviruses for medical applications from Cardiff University’s School To take place to trigger this ultra-rare side effect,” said Alan Parker, an expert “VITT only happens in extremely rare cases because a chain of complex events needs Scientists to investigate vaccine-induced immune thrombotic thrombocytopenia (VITT),Īlso known as thrombosis with thrombocytopenia syndrome (TTS), a life-threateningĬondition seen in a very small number of people after receiving the Oxford-AstraZeneca Researchers from Cardiff University and Arizona State University worked with AstraZeneca

In a very small number of people after the vaccine is administered. Their findings, which were recently published in the international journal Science Advances, suggest it is the viral vector – in this case an adenovirus used to shuttle theĬoronavirus’ genetic material into cells – and the way it binds to platelet factorĤ (PF4) once injected that could be the potential mechanism that triggers blood clots Image Credit: Daipayan Sarkar/Josh Vermaas To cryo-electron density map (3.07 Å) using symmetry restraints molecular dynamicsįlexible fitting (MDFF). All atom model for ChADOx1 viral vector (Oxford-AstraZeneca COVID-19 vaccine) fitted In minute detail to understand whether the ultra-rare side effect could be linked The global team used state-of-the-art technology to analyze the AstraZeneca vaccine An international team of scientists, including Michigan State University researchers,īelieve they may have found a molecular mechanism behind the extremely rare bloodĬlots linked to adenovirus COVID-19 vaccines.

Chimpanzee adenovirus